New measure of sperm age may be predictor of pregnancy success
A novel technique to measure the age of male sperm has the potential to predict the success and time it takes to become pregnant, according to a newly published study by researchers at the Wayne State University School of Medicine.
"Sperm epigenetic clock associates withpregnancy outcomesin thegeneral population," published in the journalHuman Reproduction, found thatspermepigenetic aging clocks may act as a novel biomarker to predict couples' time to pregnancy. The findings also underscore the importance of the male partner inreproductive success.
"Chronological age is a significant determinant of reproductive capacity and success among couples attempting pregnancy, but chronological age does not encapsulate the cumulative genetic and external—environmental conditions- 由于该研究的“真实”生物时代的替代量度，”该研究的首席作者J. Richard Pilsner博士说。Pilsner博士是Robert J. Sokol，M.D.。，在WSU的C.S. Mott人类增长与发展中心的分子妇产科主席以及分子遗传学和不孕症主任。生殖结果。因此，捕获精子生物年龄的能力可能会提供一个新的平台，以更好地评估男性对生殖成功的贡献，尤其是在不育夫妇中。”
Sperm epigenetic aging is the biological, rather than the chronological, aging of sperm. The study found a 17% lower cumulative probability of pregnancy after 12 months for couples with male partners in older compared to younger sperm epigenetic aging categories. The study involved 379male partnersof couples who discontinued the use of contraception for the purpose of becoming pregnant.
The study also found a higher epigenetic aging of sperm in men who smoked.
The results, Dr. Pilsner said, indicate that higher sperm epigenetic aging is associated with a longer time to become pregnant in couples not assisted by fertility treatment, and among couples that achieved pregnancy, with shorter gestation.
The strong association between sperm epigenetic aging and pregnancy probability and its slowing or reversal through lifestyle choices and/or pharmacological interventions warrants further investigation. In addition, because older fathers have an increased risk of children with adverse neurological outcomes, it is important to understand the potential relation of sperm epigenetic aging on children's health and development.
"There is a critical need for new measures of male fecundity for assessing overall reproductive success among couples in the general population," Dr. Pilsner said. "These data show that our sperm epigenetic clocks may fulfill this need as a novel biomarker that predicts pregnancy success among couples not seeking fertility treatment. Whilechronological ageof both partners remains a significant predictor of reproductive success, our clocks likely recapitulate both external and internal factors that drive the biological aging of sperm. Such a summary measure of sperm biological age is of clinical importance, as it allowscouplesin the general population to realize their probability of achieving pregnancy during natural intercourse, thereby informing and expediting potential infertility treatment decisions."
Dr. Pilsner advised that because those studied were largely Caucasian, greater and more diverse cohorts are necessary to confirm the association between sperm epigenetic aging and couple pregnancy success in other races and ethnicities.